Collaborative Articles
CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β.
Jayaraman V, Prise IE, Kästele V, Tamburrano S, Wemyss K, Bridgeman HM, Daw RH, Strangward P, Sanderson A, Cruickshank SM, Konkel JE, Chew C, Yao C, Anderson CJ, Priller J, McColl B, Munro DAD, Martens L, Scott CL, Guilliams M, Adamson AD, Grainger JR, Shaw TN.
J Exp Med, 2026. Pubmed
IL-4 treatment induces apoptosis of blood monocytes and proliferation of recruited injury-associated macrophages to resolve liver injury.
Lynch RW, Louwe PA, Martens L, Candela ME, Bain CC, Hawley C, Henderson NC, Ramachandran P, Bénézech C, Scott CL, Guilliams M, Saeys Y, Forbes SJ, Allen JE, Jenkins SJ.
Cell Rep, 2026. Pubmed
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.
Vanneste D, Peng W, Liu ZZ, Hamaïdia M, Rocca RL, Abinet J, Balthazar A, Perin F, Hego A, Cataldo D, Bureau F, Compère P, Machiels B, Scott CL, Radermecker C, Marichal T.
Immunity, 2026. Pubmed
Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody.
Van Damme KFA, Sichien D, Van der Borght K, Van Moorleghem J, Van Gassen S, Jorssen J, De Winter S, De Leeuw E, Wang C, Chai Q, Zumsteg AB, Schmid MA, Bosteels V, De Bleser P, Vanheerswynghels M, De Prijck S, Bujko A, De Nolf C, Schuijs MJ, Van Den Eeckhout B, Rogiers I, Browaeys R, Thielemans F, Quintelier K, D'Hont J, Hochepied T, Isnard Petit P, Augier S, Courtois R, Verwaerde S, Vanhee S, Schetters S, Scott CL, Aerts S, Saeys Y, Korman AJ, Benigni F, Corti D, Janssens S, Vandamme N, Baptista AP, Desmet C, Elewaut D, Hammad H, Morel A, Vivier E, Sônego F, Thiam K, Voet S, Balbino B, Lambrecht BN.
Sci Immunol, 2026. Pubmed
Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis.
Batchuluun B, Thoné T, Djalalvandi A, Fayyazi R, Deo P, Yabut JM, Maggiore S, Vanneste B, Gautam J, Townsend LK, Ahmadi E, Jabile MJT, Morrow M, Desjardins EM, Tsakiridis EE, Rehal S, Khan WI, Wang D, Scott CL, Steinberg GR.
Cell rep, 2025. Pubmed
STAT1 drives the immune landscape of murine Toll-like receptor 9-induced liver inflammation.
De Visscher A, Beliën J, Bernaerts E, Vandeput M, Malengier-Devlies B, Prenen F, Meers H, Sokol L, Mitera T, Berghmans N, Anak S, Govaere O, Van den Steen P, Lamote J, Vandamme N, Bujko A, Scott CL, Wouters CH, Matthys P.
JHEP, 2025. Pubmed
Kupffer cell programming by maternal obesity triggers fatty liver disease.
Huang H, Balzer NR, Seep L, Splichalova I, Blank-Stein N, Viola MF, Franco Taveras E, Acil K, Fink D, Petrovic F, Makdissi N, Bayar S, Mauel K, Radwaniak C, Zurkovic J, Kayvanjoo AH, Wunderling K, Jessen M, Yaghmour MH, Kenner L, Ulas T, Grein S, Schultze JL, Scott CL, Guilliams M, Liu Z, Ginhoux F, Beyer MD, Thiele C, Meissner F, Hasenauer J, Wachten D, Mass E.
Nature, 2025. Pubmed
SPArrOW: a flexible, interactive and scalable pipeline for spatial transcriptomics analysis.
Pollaris L*, Vanneste B*, Rombaut B, Defauw A, Vernaillen F, Mortier J, Vanhenden W, Martens L, Thoné T, Hastir JF, Bujko A, Saelens W, Marine JC, Nelissen H, Van Hamme E, Seurinck R, Scott CL, Guilliams M⁺ and Saeys Y⁺.
bioRxiv, 2024. Pubmed
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver.
Perry AS*, Hadad N*, Chatterjee E*, Jimenez-Ramos M#, Farber-Eger E#, Roshani R#, …,Fallowfield JA⁺, Banovich NE⁺, Das S⁺, Shah R⁺.
Cell Reports Medicine, 2024. Pubmed
Host-pathogen interactions in the Plasmodium-infected mouse liver at spatial and single-cell resolution.
Hildebrandt F, Iturritza MU, Zwicker C, Vanneste B, Van Hul N, Semle E, Quin J, Pascini T, Saarenpää S, He M, Andersson ER, Scott CL, Vega-Rodriguez J, Lundeberg J, Ankarklev J.
Nat Commun, 2024. Pubmed
Implementing distinct spatial proteogenomic technologies: opportunities, challenges, and key considerations.
Verstappe B, Scott CL.
Clin Exp Immunol, 2024. Pubmed
Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis.
De Muynck K, Heyerick L, De Ponti FF, Vanderborght B, Meese T, Van Campenhout S, Baudonck L, Gijbels E, Rodrigues PM, Banales JM, Vesterhuus M, Folseraas T, Scott CL, Vinken M, Van der Linden M, Hoorens A, Van Dorpe J, Lefere S, Geerts A, Van Nieuwerburgh F, Verhelst X, Van Vlierberghe H, Devisscher L.
Hepatology, 2024. Pubmed
Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma.
Vanderborght B, De Muynck K, Gijbels E, Lefere S, Scott CL, Guilliams M, Beschin A, Vinken M, Verhelst X, Geerts A, Van Vlierberghe H, Devisscher L.
Int J Cancer, 2023. Pubmed
A20 is a master switch of IL-33 signaling in macrophages and determines IL-33-induced lung immunity.
Holgado A, Liu Z, Aidarova A, Mueller C, Haegman M, Driege Y, Kreike M, Scott CL, Afonina IS⁺, Beyaert R⁺.
J Allergy Clin Immunol, 2023. Pubmed
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes.
Gainullina A, Mogilenko DA, Huang LH, Todorov H, Narang V, Kim KW, Yng LS, Kent A, Jia B, Seddu K, Krchma K, Wu J, Crozat K, Tomasello E, Dress R, See P, Scott C, Gibbings S, Bajpai G, Desai JV, Maier B, This S, Wang P, Aguilar SV, Poupel L, Dussaud S, Zhou TA, Angeli V, Blander JM, Choi K, Dalod M, Dzhagalov I, Gautier EL, Jakubzick C, Lavine K, Lionakis MS, Paidassi H, Sieweke MH, Ginhoux F, Guilliams M, Benoist C, Merad M, Randolph GJ, Sergushichev A, Artyomov MN; ImmGen Consortium.
Cell Rep, 2023. Pubmed
Kupffer Cells Contested as Early Drivers in the Pathogenesis of Primary Sclerosing Cholangitis.
De Muynck K, Vanderborght B, De Ponti FF, Gijbels E, Van Welden S, Guilliams M, Scott CL, Beschin A, Vinken M, Lefere S, Geerts A, Verhelst X, Van Vlierberghe H, Devisscher L.
Am J Pathol, 2023. Pubmed
Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues.
Scheyltjens I*, Van Hove H*, De Vlaminck K, Kancheva D, Bastos J, Vara-Pérez M, Pombo Antunes AR, Martens L, Scott CL, Van Ginderachter JA, Saeys Y, Guilliams M, Vandamme N, Movahedi K.
Nat Protoc, 2022. Pubmed
A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism.
Catrysse L*, Maes B*, Mehrotra P, Martens A, Hoste E, Martens L, Maueröder C, Remmerie A, Bujko A, Slowicka K, Sze M, Vikkula H, Ghesquière B, Scott CL, Saeys Y, van de Sluis B, Ravichandran K, Janssens S, van Loo G.
Cell Rep, 2021. Pubmed
ILC3s control splenic cDC homeostasis via lymphotoxin signaling.
Vanderkerken M*, Baptista AP*, De Giovanni M*, Fukuyama S, Browaeys R, Scott CL, Norris PS, Eberl G, Di Santo JP, Vivier E, Saeys Y, Hammad H, Cyster JG, Ware CF, Tumanov AV⁺, De Trez C⁺, Lambrecht BN⁺.
J Exp Med, 2021. Pubmed
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Bosteels C*, Neyt K*, Vanheerswynghels M, van Helden MJ, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams DL, Tang SC, Mayer JU, Ronchese F, Scott CL, Hammad H, Guilliams M⁺, Lambrecht BN⁺.
Immunity, 2020. Pubmed
Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury. Ydens E*, Amann L*, Asselbergh B, Scott CL, Martens L, Sichien D, Mossad O, Blank T, De Prijck S, Low D, Masuda T, Saeys Y, Timmerman V, Stumm R, Ginhoux F, Prinz M⁺, Janssens S⁺, Guilliams M⁺. Nature Neurosci, 2020. Pubmed
OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G.
Cell Rep, 2020. Pubmed
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis.
Van Wyngene L, Vanderhaeghen T, Timmermans S, Vandewalle J, Van Looveren K, Souffriau J, Wallaeys C, Eggermont M, Ernst S, Van Hamme E, Gonçalves A, Eelen G, Remmerie A, Scott CL, Rombouts C, Vanhaecke L, De Bus L, Decruyenaere J, Carmeliet P, Libert C.
EMBO Mol Med, 2020. Pubmed
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Bonnardel J*, TJonck W*, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y⁺, Guilliams M⁺.
Immunity, 2019 Pubmed
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA*, Saeys Y*, Movahedi K.
Nature Neurosci, 2019. Pubmed
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Voet S*, Mc Guire C*, Hagemeyer N*, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G.
Nat Commun, 2018. Pubmed
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.
Scott CL*, TJonck W*, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A⁺, Saeys Y⁺, Guilliams M⁺.
Immunity, 2018. Pubmed
Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells.
Van der Borght K, Scott CL, Martens L, Sichien D, Van Isterdael G, Nindl V, Saeys Y, Boon L, Ludewig B, Gillebert TC, Lambrecht BN.
Front Immunol, 2018. Pubmed
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.
Normand S*, Waldschmitt N*, Neerincx A*, Martinez-Torres RJ*, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S, Bohn E, Ryffel B, Poulin LF⁺, Kufer TA⁺, Chamaillard M⁺.
Nat Commun, 2018. Pubmed
Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.
Van der Borght K, Scott CL, Nindl V, Bouché A, Martens L, Sichien D, Van Moorleghem J, Vanheerswynghels M, De Prijck S, Saeys Y, Ludewig B, Gillebert T, Guilliams M, Carmeliet P, Lambrecht BN.
Cell Rep, 2017. Pubmed
TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine.
Bain CC*, Montgomery J*, Scott CL, Kel JM, Girard-Madoux MJH, Martens L, Zangerle-Murray TFP, Ober-Blöbaum J, Lindenbergh-Kortleve D, Samsom JN, Henri S, Lawrence T, Saeys Y, Malissen B, Dalod M, Clausen BE⁺, Mowat AM⁺.
Nat Commun, 2017. Pubmed
Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool.
Devisscher L*, Scott CL*, Lefere S, Raevens S, Bogaerts E, Paridaens A, Verhelst X, Geerts A, Guilliams M⁺, Van Vlierberghe H⁺.
Cell Immunol, 2017. Pubmed
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.
Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A⁺, Guilliams M⁺.
Nature Commun, 2016. Pubmed
Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages. van de Laar L, Saelens W, De Prijck S, Martens L, Scott CL, Van Isterdael G, Hoffmann E, Beyaert R, Saeys Y, Lambrecht BN, Guilliams M.
Immunity, 2016. Pubmed
The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. Scott CL*, Soen B*, Martens L, Skrypek N, Saelens W, Taminau J, Blancke G, Van Isterdael G, Huylebroeck D, Haigh J, Saeys Y, Guilliams M, Lambrecht BN⁺, Berx G⁺.
Journal of Experimental Med, 2016. Pubmed
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species.
Guilliams M*, Dutertre CA*, Scott CL*, McGovern N*, Sichien D*, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Tavernier SJ, Low I, Irac SE, Mattar CN, Sumatoh HR, Low GHL, Chung TJK, Chan DKH, Tan KK, Hon TLK, Fossum E, Bogen B, Choolani M, Chan JKY, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B, Ginhoux F.
Immunity, 2016. Pubmed
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities.
Bain CC, Hawley CA, Garner H, Scott CL, Schridde A, Steers NJ, Mack M, Joshi A, Guilliams M, Mowat AM, Geissmann F, Jenkins SJ.
Nat Commun, 2016. Pubmed
IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively. Sichien D, Scott CL, Martens L, Vanderkerken M, Van Gassen S, Plantinga M, Joeris T, De Prijck S, Vanhoutte L, Vanheerswynghels M, Van Isterdael G, Toussaint W, Madeira FB, Vergote K, Agace WW, Clausen BE, Hammad H, Dalod M, Saeys Y, Lambrecht BN, Guilliams M.
Immunity, 2016. Pubmed
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.
Laoui D*, Keirsse J*, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M⁺, Van Ginderachter JA⁺.
Nat Commun, 2016. Pubmed
Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells.
Cerovic V, Houston SA, Westlund J, Utriainen L, Davison ES, Scott CL, Bain CC, Joeris T, Agace WW, Kroczek RA, Mowat AM, Yrlid U, Milling SW.
Mucosal Immunol, 2015. Pubmed
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells.
Scott CL, Bain CC, Wright PB, Sichien D, Kotarsky K, Persson EK, Luda K, Guilliams M, Lambrecht BN, Agace WW, Milling SW, Mowat AM.
Mucosal Immunol, 2015. Pubmed
Type 2 innate lymphoid cells drive CD4+ Th2 cell responses.
Mirchandani AS, Besnard AG, Yip E, Scott C, Bain CC, Cerovic V, Salmond RJ⁺, Liew FY⁺.
J Immunol, 2014. Pubmed
The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.
Sauter KA*, Pridans C*, Sehgal A, Bain CC, Scott C, Moffat L, Rojo R, Stutchfield BM, Davies CL, Donaldson DS, Renault K, McColl BW, Mowat AM, Serrels A, Frame MC, Mabbott NA, Hume DA.
PLoS One, 2014. Pubmed
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.
Bain CC*, Bravo-Blas A*, Scott CL, Perdiguero EG, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM.
Nat Immunol, 2014. Pubmed
Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103(+) CD11b(+) DCs in the intestinal lamina propria.
Scott CL, Tfp ZM, Beckham KS, Douce G, Mowat AM.
Eur J Immunol, 2014. Pubmed
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
Martin JC, Bériou G, Heslan M, Chauvin C, Utriainen L, Aumeunier A, Scott CL, Mowat A, Cerovic V, Houston SA, Leboeuf M, Hubert FX, Hémont C, Merad M, Milling S, Josien R.
Mucosal Immunol, 2014. Pubmed
Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors.
Bain CC, Scott CL, Uronen-Hansson H, Gudjonsson S, Jansson O, Grip O, Guilliams M, Malissen B, Agace WW, Mowat AM.
Mucosal Immunol, 2013. Pubmed
Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells.
Cerovic V, Houston SA, Scott CL, Aumeunier A, Yrlid U, Mowat AM, Milling SW.
Mucosal Immunol, 2013. Pubmed
Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling.
Van Damme KFA, Sichien D, Van der Borght K, Van Moorleghem J, Van Gassen S, Jorssen J, De Winter S, De Leeuw E, Wang C, Chai Q, Zumsteg AB, Schmid MA, Bosteels V, De Bleser P, Vanheerswynghels M, De Prijck S, Bujko A, De Nolf C, Schuijs MJ, Van Den Eeckhout B, Rogiers I, Browaeys R, Thielemans F, Quintelier K, D'Hont J, Hochepied T, Isnard Petit P, Augier S, Courtois R, Verwaerde S, Vanhee S, Schetters S, Scott CL, Aerts S, Saeys Y, Korman AJ, Benigni F, Corti D, Janssens S, Vandamme N, Baptista AP, Desmet C, Elewaut D, Hammad H, Morel A, Vivier E, Sônego F, Thiam K, Voet S, Balbino B, Lambrecht BN.
Sci Immunol. 2026 Pubmed